With contributions from leading international academics across the biological sciences, this handbook takes a critical look at the key contemporary issues and debates in the field.
Reflecting the shift from genetics to genomics in the pharmaceutical sphere, this Second Edition traces the evolution of the science of pharmacogenetics and gathers research from the forefront of the field-spanning the most influential breakthroughs in molecular diagnostics, metabonomics, proteomics, bioinformatics, disease mapping, pharmacodynamic
This book is a unique resource for state-of-the-art research findings on biotechnological innovations in the area of industrial and therapeutic enzymes, and special-function and extreme-nature enzymes such as ribozymes, therozymes, cold-adapted enzymes, etc, covering all aspects such as the producing micro-organisms, their mode of cultivation, downstream processing and applications.
For two decades, Understanding Clinical Papers has been helping students and professionals understand the research that supports evidence-based practice.
The Food and Drug Administration (FDA) now requires that all clinical trials for drugs that affect the central nervous systemincluding psychiatric drugsare assessed for whether that drug might cause suicidal ideation or behavior.
The purpose of this publication is to introduce a new, simpler and more effective way in which to interpret pharmaceutical aerosol particle size data from orally inhaled products (OIPs).
In the opening chapter, authors discuss the current literature that describes the application of Palliative Medicine services in advanced cancer, models of Palliative Care delivery by site and mode of practice, cost-effectiveness of early Palliative Medicine referral patterns and national and international Palliative Medicine practice and referral guidelines.
The authoritative guide for Data Monitoring Committees fully revised and updated The number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy.
This invaluable guide shows students and professionals how measurements and data can be used to balance quality services and financial viability and how measures can help to evaluate and improve organizational, clinical, and financial processes.
Preeminent Experts Update a Well-Respected BookTaking into account the regulatory and scientific developments that have occurred since the second edition, Design and Analysis of Bioavailability and Bioequivalence Studies, Third Edition provides a complete presentation of the latest progress of activities and results in bioavailability and bioequiva
Anaerobic Bacteriology: Clinical and Laboratory Practice, Third edition discusses the importance of the non-sporing anaerobic bacteria as a significant cause of infection in man.
This comprehensive and useful handbook represents a definitive up-to-date compendium of key in vitro bioassay methods that are employed to quantify and validate the anticancer activity of a drug candidate before it makes its way in to animal or clinical trials.
A thorough treatment of the statistical methods used to analyze doubly truncated data In The Statistical Analysis of Doubly Truncated Data, an expert team of statisticians delivers an up-to-date review of existing methods used to deal with randomly truncated data, with a focus on the challenging problem of random double truncation.
Scientists now understand that cancer is a genetic disease and cutting -edge molecular therapies are making their way from the laboratory into clinical practice.
Juvenile homicide and fatal maltreatment remain serious and pervasive problems in the developed world and especially in the United States, where in 2005 some 1,500 children died from neglect and physical abuse.
Helps researchers in proteomics and oncology work together to understand, prevent, and cure cancer Proteomic data is increasingly important to understanding the origin and progression of cancer; however, most oncologic researchers who depend on proteomics for their studies do not collect the data themselves.
More and more biologists, chemists, pharmacologists, toxicologists, gov- ernmental agencies, and "e;food control"e; (regulatory) officials around the world are finding it increasingly difficult to keep abreast of the technical literature in the pesticide field; indeed, many libraries do not have even a small proportion of the journals and other sources that now regularly contain research, development, and application information about all aspects of modern chemical pest control.
Quality Assurance Management: A Comprehensive Overview of Real-World Applications for High Risk Specialties demonstrates how to best design and implement standard operating procedures (SOPs) to ensure protocol and regulation adherence.
**Longlisted for the Baillie Gifford Prize 2023**A NEW YORK TIMES, DAILY TELEGRAPH, ECONOMIST, MAIL ON SUNDAY and GUARDIAN BOOK OF THE YEARFrom the dawn of life itself, every being that has ever lived owes its existence to the cell.
The public is bombarded daily with reports about risk factors, many conflicting with each other, others accepted as "e;scientific truth"e; for awhile, then scientifically disproved, yet others questionable that later prove to be true.
Recent Advancement in ProdrugsDrugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain).
Nuclear Medicine in Urology and Nephrology, Second Edition describes and explains the applications of nuclear medicine to urology and nephrology and their role in clinical diagnosis.
Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability.
This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure.
One of the primary purposes and obligations of science, in addition to - derstandingnatureingeneralandlifeinparticular, istoassistinenhancing the quality and longevity of life, indeed a most daunting challenge.
