Medical research

Offering a wide array of illustrations and tables in every chapter, this book extensively covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems-helping those new to the subject understand the importance of allosterism and providing th

While the genomic revolution has quickly led to the deposit of more than 30,000 structures in the protein data bank (PDB), less than one percent of those contributions represent membrane proteins despite the fact that membrane proteins constitute some 20 percent of all proteins.

Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments.

Continuing advances in biomedical research and statistical methods call for a constant stream of updated, cohesive accounts of new developments so that the methodologies can be properly implemented in the biomedical field.

Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues.

This text provides a solid understanding of the various statistical topics relevant to the design, monitoring, and analysis of a clinical trial.

An ideal text for biotechnologists, protein chemists, and biochemists, Functional Protein Microarrays in Drug Discovery explores all aspects of functional protein microarrays, including basic principles, methods, and applications.

Written for practitioners in both the drug and biotechnology industries, this handbook carefully compiles the current regulatory requirements to correctly and properly validate a new or modified analytical method.

A True Insider's Guide to the Field - Then and Now Until now, there has not been a book that effectively addresses the historical basis of protein discovery.

Preeminent Experts Update a Well-Respected BookTaking into account the regulatory and scientific developments that have occurred since the second edition, Design and Analysis of Bioavailability and Bioequivalence Studies, Third Edition provides a complete presentation of the latest progress of activities and results in bioavailability and bioequiva

In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics.

Integrating various technologies with informational systems provides vast improvements to the overall research and development that occur in the biopharmaceutical industry.

The Handbook of Assay Development in Drug Discovery describes all the tools currently available for performing various assay techniques.

The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets.

As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies.

In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified.

This book reviews the history, regulatory status, pharmacopeial specifications, and harmonization of pharmaceutical excipients in the United States and Europe, and provides a comprehensive understanding of the current scientific basis for safety evaluation and risk assessment.

Imaging technologies are receiving much attention in the pharmaceutical industry because of their potential for accelerating drug discovery and development.

A Single Source on Parallel Synthesis for Lead OptimizationThe end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening.

Reveals important new results from clinical trials conducted in Scandinavia, Scotland, Australia, Canada, and the United States.

Two decades after radiocarbon dating declared the Turin Shroud a mediaeval fake, brand-new historical discoveries strongly suggest that this famous cloth, with its extraordinary photographic imprint, is genuinely Christ's shroud after all.

Adequate health and health care is no longer possible without proper data supervision from modern machine learning methodologies like cluster models, neural networks, and other data mining methodologies.

This fascinating volume delves into the forefront of pharmaceutical research to shed light on the ground-breaking methodologies and technologies driving advancements in drug discovery today.

This collection presents up-to-the-minute qualitative research methodologies creatively developed by and within nursing.

This book is a joint package of a practical manual on how to undertake meta-analysis in medicine together with an accompanying CD-ROM.

Animal cell technology is a growing discipline of cell biology which aims not only to understand structures, functions and behaviors of differentiated animal cells, but also to ascertain their abilities to be used for industrial and medical purposes.

Congenital malformations are worldwide occurrences striking in every condition of society.

In clinical medicine appropriate statistics has become indispensable to evaluate treatment effects.

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures.

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterized by the complexity of causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures.

Residues from agriculture and the food industry consist of many and varied wastes, in total accounting for over 250 million tonnes of waste per year in the UK alone.

Observations Plus Recipes It has been said that science is the orderly collection of facts about the natural world.

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures.

Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function.

Obesity has reached epidemic proportions globally and presents a major challenge to policy makers and clinicians alike.

"e;There is hardly a reason to circumcise a little boy for medical reasons because those medical reasons don't exist"e;, said Dr.

Nonlinear dynamics has become an important field of research in recent years in many areas of the natural sciences.

The truth is, few people know the first thing about clinical research.

Lipids are functionally versatile molecules.

Phase transitions occur throughout nature.

Johannes Klumpers Biotechnologies, such as genetic engineering, cloning and biodiversity, raise many legal and ethical concerns, so it is important that people understand these issues and feel able to express their opinions.

"e;Immunosenescence"e; is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far.

Proteins lie at the heart of almost all biological processes and have an incredibly wide range of activities.

Current state of knowledge and gaps in experimental evidence related to the physiologic role and toxicity of trace elements in human health were presented and discussed at an international joint conference in Hersonissos, Crete-Greece, in October 2007.

Surprisingly what separates us from the open environment all around us sometimes is a single layer of epithelial cells.

The incessant development of quantum chemistry since the appearance of the Schrodinger * equation has turned this area into a respectable branch of science with unprecedented capabilities.

With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge.