Medical genetics

Provides an introduction to the various statistical techniques involved in medical research and drug development with a focus on estimating the success probability of an experiment Success Probability Estimation with Applications to Clinical Trials details the use of success probability estimation in both the planning and analyzing of clinical trials and in widely used statistical tests.

Written by the successful author team of Sandy Primrose and Richard Twyman, Genomics: Applications in Human Biology is a topical book showing how the new science of genomics is adding impetus to the advances in human health provided by biotechnology.

This book comprises a collection of chapters describing topics from traditional radiation cytogenetic analysis methods to the modern fluorescence based-analysis and high throughput automatic analysis methods.

The discovery in the late 1940's that sickle cell anemia is a "e;molecular disease"e; of hemoglobin was the crucial advance that gave birth to the scientific discipline of human molecular genetics.

Using both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies.

Translational mitochondrial medicine applies the knowledge of experimental medicine in clinical practice, it is a prospective direction of the development of mitochondrial medicine.

This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours.

The ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable.

This book illustrates the role of randomness and noise in living organisms.

Advances in genetics, molecular biology and gene delivery technologies in recent years have led to new gene therapy strategies for treatment of a variety of diseases.

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide.

The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters.

The fields of rare diseases research and orphan products development continue to expand with more products in research and development status.

This book examines the visual representations used in the popular communication of genetics.

"e;Gene Therapy for Cartilage and Bone Tissue Engineering"e; outlines the tissue engineering and possible applications of gene therapy in the field of biomedical engineering as well as basic principles of gene therapy, vectors and gene delivery, specifically for cartilage and bone engineering.

Cancer genetics is a field of daunting breadth and depth.

According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition.

A thirty-year quest, from genes to pain-signaling neurons to people with a rare genetic disorder that makes them feel they are on fire.

An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors.

In this book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research.

This handbook offers original, critical perspectives on different approaches to the history of biology.

Due to sensitive molecular biological techniques, our understanding of chromosomal aberrations is steadily increasing.

Who are the Jews--a race, a people, a religious group?

The increasing demand for innovative techniques arises from the lack of safe, effective, and patient-friendly therapies for neurodegenerative disorders.

Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century.

This volume provides a comprehensive collection of DNA assembly protocols that will prove useful for any researcher interested in molecular cloning, synthetic biology, or DNA manipulation.

Molecular Genetics of Cancer, Second Edition provides an authoritative and up to date review of the key genes known to be critical in the development or progression of cancer.

Fundamentals of Brain and Behavior provides an accessible introduction to the study of human neuroscience.

The molecular and genetic signatures of cancer are represented in the peripheral circulation and other body fluids, giving rise to the "e;liquid biopsy"e; concept.

The study of carbonic anhydrase has spanned multiple generations of scientists.

Mosaicism is a powerful biologic concept, originally developed from studying plants and animals.

The second volume in the Stem Cells series concentrates on the mechanisms of stem cell regeneration in the adult organism with a view towards understanding how lost tissue can be replaced during adulthood and aging.

This volume of Molecular Biology of Hematopoiesis is dedicated to many inter- national scientists and clinicians for their contribution to the field of Hematology/ Oncology presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, which was held in Bormio, Italy, June 25-29, 1998.

Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists.

This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases.

The present monograph develops a versatile and profound mathematical perspective of the Wright--Fisher model of population genetics.

This book introduces different Rare Genetic Disorders (RGDs), and challenges in their diagnosis.

Texts on inborn errors of metabolism (IEMs) have traditionally focused on classical biochemistry, clinical presentation, and standard treatment approaches.

As cells mature they naturally stop dividing and enter a period called senescence.

This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging.

The volume provides a review of statistical development and application in the area of human genomics, including candidate gene mapping, linkage analysis, population-based genome-wide association, exon sequencing, and whole genome sequencing analysis.

This book entitled "e;Cancer Stem Cell Markers and Related Network Path-ways"e; is about cancer stem cell (CSC) markers and the molecular network pathways.

This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging.

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors.

Thieme Test Prep for the USMLE(R): Medical Histology and Embryology is the choice of medical students.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind.