Medical genetics

This book contains the proceedings of the first meeting on invertebrate immunity ever sponsored as a summer research conference by the Federation of American Societies for Experimental Biology (FASEB).

PAS proteins control numerous physiological and developmental events, and span phylogeny from bacteria to man.

As a dynamic, interdisciplinary field, behavior genetics and its evolution are being followed closely by scientists across the psychological and medical domains.

This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects.

World of Unstable Mutations The book "e;Triplet Repeat Diseases of the Nervous System"e; overviews the lat- est data on several disorders associated with unstable mutations.

Given the latest advances in cancer research, which includes basic research and its derived diagnostic, clinical, and therapeutic applications, the book New Trends in Cancer for the 21st Century is written by individuals such as molecular biologists, whose tasks are to decipher, after sequencing the human genome, those new genes and pathways involved in the carcinogenesis process; clinical and molecular pathologists, who apply these discoveries for the molecular diagnosis and characterization of the tumor; and clinical oncologists, who treat patients.

Genetic Engineering, Volume 25 contains discussions of contemporary and relevant topics in genetics, including: - Genotyping by Mass Spectrometry;- Development of Targeted Viral Vectors for Cardiovascular Gene Therapy; - Practical Applications of Rolling Circle Amplification of DNA Templates; - Bacterial ION Channels; - Applications of Plant Antiviral Proteins;- The Bacterial Scaffoldin: Structure, Function and Potential Applications in the Nanosciences.

A new perspective on brain function depends upon an understanding of the interaction and integration of excitation and inhibition.

This book introduces readers to Next Generation Sequencing applications in medical genetics.

Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades.

Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues.

The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the "e;new"e; MS susceptibility loci are immune-response genes.

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There are several types of damage that can be found in the male gamete.

Although the phenomenon of lateral gene transfer has been known since the 1940's, it was the genomics era that has really revealed the extent and many facets of this evolutionary/genetic phenomenon.

The goal of this book is to introduce the biological and technical aspects of next generation sequencing methods, as well as algorithms to assemble these sequences into whole genomes.

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The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade.

Stem Cell therapy for lysosomal diseases (LSDs) is developing rapidly.

Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.

Research in Crohn's disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years.

Undoubtedly, Drosophila melanogaster, fruit fly, has proved to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists.

This book will provide an overview of basic epigenetic phenomena; interaction between epigenetic and genetic factors; and the influence of epigenetic factors on inheritance.

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In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults.

Along with psychopathology, cognition has been one of the primary phenotypic focal points of the field of behavior genetics since its inception.

Alzheimer's Disease is the most common form of dementia.

The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells.

Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males.

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In recent years, epigenetic approaches to existing scientific problems have offered many new and exciting perspectives.

Pancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth.

This title will focus on the study of human interphase chromosomes and its relation to health and disease.

Comprehensive, thoroughly updated, and expanded, Neuromuscular Disorders in Clinical Practice, Second Edition encompasses all disorders of the peripheral nervous system, covering all aspects of neuromuscular diseases from diagnosis to treatment.

Traditionally, genetics laboratory exercises at the university level focus on mono- and dihybrid crosses and phenotypic analysis-exercises under traditional time, materials, and process constraints.

In recent years, owing to the fast development of a variety of sequencing technologies in the post human genome project era, sequencing analysis of a group of target genes, entire protein coding regions of the human genome, and the whole human genome has become a reality.

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease.

Circadian rhythms are such an innate part of our lives that we rarely pause to speculate why they even exist.

In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses.

Multiple myeloma is a plasma cell malignancy characterized by complex heterogenous cytogenetic abnormalities that accounts for 1.

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The hereditary retinopathy, retinitis pigmentosa (RP), which affects 1 in 3,500 people worldwide, is the most common cause of registered visual handicap among those of the working age in developed countries.

GW bodies are novel cytoplasmic foci that were discovered and named by Dr.

This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation.

Germ cells in sexually reproducing metazoa, through the germline lineage, are the route by which genetic material and cytoplasmic constituents are passed from one generation to the next in the continuum of life.

This book is a collection of articles written by prominent scientists who gathered in the city of Recife, Brazil, 23-27 October 2010, celebrating the 10th International Symposium on Yersinia.

Mitochondrial cytopathies are mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation.