Pre-clinical medicine: basic sciences

Dysmenorrhea is estimated to effect upwards of 70% of women during their lifetime and "e;heavy menstrual periods"e; is one of the most frequently given reasons for hysterectomy in the United States.

This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections.

This book provides a cutting-edge review of polyglutamine disorders.

The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function.

This ambitious sourcebook surveys both the traditional basis for and the present  state of indigenous women's reproductive health in Mexico and Central America.

This atlas focuses on selected aspects of cochlear anatomy as illustrated by material prepared by the microdissection technique, a three-dimensional perspective not possible with standard histological approaches.

This unique, comprehensive text on the male factor infertility experience centers on the current background, applications and techniques for intracytoplasmic sperm injection (ICSI), one of the more commonly utilized procedures in modern assisted reproduction for male infertility, offering insights into the rationale and indications for ICSI and providing an up-to-date discussion on male factor diagnostic tests and microsurgical techniques for ICSI itself.

Whatever are your beliefs, background, education, political views or interests, one thing is sure: this book will engage you, teach you something new, and more importantly make you to re-think deeply about critical aspects of your daily-life, including sex, love, food, physical activities, diseases, work and stress, and how you see and deal with other people, other animals, and the planet in general.

The over-arching goal of this volume is to help infertility practitioners evaluate and manage their patients with poor semen quality.

Atrial Fibrillation from an Engineering Perspective provides an up-to-date overview of techniques developed for acquisition, modeling, and analysis of noninvasive, bioelectrical signals reflecting this common arrhythmia.

This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature.

This volume of the series SpringerBriefs in Space Life Sciences describes findings from space and accompanying ground research related to spatial orientation, posture and locomotion, cognition and psychomotor function.

This book offers a collection of expert reviews on the use of plant-based antioxidant therapies in disease prevention and treatment.

This proceedings volume highlights a selection of papers presented at the Sixth International Conference on High Performance Scientific Computing, which took place in Hanoi, Vietnam on March 16-20, 2015.

The fields of rare diseases research and orphan products development continue to expand with more products in research and development status.

This book spans topics in both congenital and acquired right heart disease providing readers with detailed information on the physiology, anatomy and myocardial mechanics of the right ventricle (RV), while describing the use of echo and MRI imaging to diagnose, and new developments in surgery and cardiac catheterization to treat.

This is the first book compiling current research on the gut-bone signaling axis and its implications in the pathophysiology of GI and bone diseases.

This Brief is devoted to the CFTR protein and cystic fibrosis, and it provides an updated perspective of the genetic, functional and cellular processes involved in this conformational disorder.

This title reflects the exponential growth in the knowledge and information on this subject and defines the extensive clinical translation of cardiovascular genetics and genomics in clinical practice.

This book describes the field of osteocardiology, an exciting and new sub-discipline within cardiovascular science, which will become the cornerstone for defining the timing and treatment of cardiovascular calcification in the future.

This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine.

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine.

This didactic book clearly and systematically describes the anatomical-surgical fundamentals of cranial neurosurgery, relating them to norm variants, imaging modalities and interdisciplinary aspects.

This volume represents an up-to-date overview on pre-Menopause and Menopause, with their respective clinical implications and therapies.

The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature.

Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life.

Since the first edition of this book was published, new knowledge has been gained on Vitiligo.

This book examines in detail the clinical implications of those diseases that either are primarily triggered by air pollution or represent direct consequences of air pollutants.

This book presents a timely collection of reviews by experts in periconception and fertilization.

This book covers the latest developments in the therapeutic implications of angiogenesis, ranging from angiogenesis in the brain, angiogenesis in cancer, angiogenesis' role in atherosclerosis and heart disease as well as metabolic disorders and peripheral vascular disease.

The mammalian genome is constantly challenged by exogenous and endogenous threats.

This book is aimed at analyzing the foundations of medical ethics by considering different moral theories and their implications for judgments in clinical practice and policy-making.

This expansive survey spotlights pervasive issues affecting girls' and women's sexual and reproductive health across the lifecourse.

The purpose of this textbook is to enable a Neuroscientist to discuss the structure and functions of the brain at a level appropriate for students at many levels of study including undergraduate, graduate, dental or medical school level.

This book aims to present a comprehensive classification of hypertensive phenotypes based on underlying target organ involvement.

Learn the basics and more of gastrointestinal diseases.

This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine.

This book concerns the mathematical modeling and computer simulation of the human stomach.

This special issue of the Handbook of Experimental Pharmacology on Heart Failure covers the entire spectrum of the field, from the current understanding and definitions of heart failure, to epidemiology and the importance of co-morbidities, clinical trial design and biomarkers, as well as imaging technologies.

As there are a number of nuances in terms of how to manage mutation carriers (both with and without a concomitant diagnosis of breast cancer), this text provides a comprehensive, state-of-the art review of this field.

Comprised of clinical cases presenting diverse clinical scenarios of uterine fibroids, this concise, practical casebook will provide clinicians in reproductive medicine and obstetrics/gynecology with the best real-world strategies to properly diagnose and treat the various presentations of fibroids they may encounter in daily clinical practice.

This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores.

This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases.

This book provides up-to-date scientific information on the pathways by which psychosocial stress can affect the auditory system and describes current approaches to the management of patients with stress-related tinnitus.

The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine.

This handbook provides insights into becoming a better and more evolved athlete.

This book is a compact question-based review of the most critical topics an obstetrician will come across in practice.

A traditional view of the Autonomic Nervous System (ANS) considers only its peripheral part: the sympathetic and parasympathetic systems.

This book offers a cutting-edge guide to hysteroscopy and provides readers with the latest and most essential information on procedure techniques, clinical advances and international developments in practice and treatment of endometrial pathology.

This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing.