In October 2017, Nobel laureate Sydney Brenner (Physiology or Medicine, 2002) gave four lectures on the history of Molecular Biology, its impact on Neuroscience and the great scientific questions that lie ahead.
Receptor Endocytosis and Signalling in Health and Disease, Part B, Volume 196 highlights the different aspects of receptor endocytosis and signaling, covering several receptors which are associated with different organs and that play a key role in normal functioning in the body, including somatostatin, Mas receptor, AMPA, Dopamine, 5-HT1-2, GABA, GPCR, nuclear receptor, Integrin, BCR, CRHR1, etc.
Cognition-Based Evolution is the first comprehensive alternative to 20th-century Neodarwinism, proposing a radical 21st-century evolutionary framework with a novel point of origination: all cells are intelligent and must measure uncertain environmental information to sustain themselves.
This volume explores the latest integrated bioprocesses and technologies used to study the production of the target recombinant protein of therapeutic or diagnostic interest; its isolation, purification, and stabilization; and the bio-interaction and structural analyses.
Cognition-Based Evolution is the first comprehensive alternative to 20th-century Neodarwinism, proposing a radical 21st-century evolutionary framework with a novel point of origination: all cells are intelligent and must measure uncertain environmental information to sustain themselves.
Unknown to most people, there are innumerable microbial species that accomplish vital ecosystem functions while residing in a suspended state in the troposphere or resting on crop canopies.
Myeloid-Derived Suppressor Cells, Volume 375 includes comprehensive and detailed reviews on the current advances in myeloid derived suppressor cells, an immature, heterogenous cell population from the myeloid lineage that has been extensively described in the last decades due to its potent immunosuppressive activity in a variety of pathologies.
This volume explores the latest integrated bioprocesses and technologies used to study the production of the target recombinant protein of therapeutic or diagnostic interest; its isolation, purification, and stabilization; and the bio-interaction and structural analyses.
Integrated Methods in Protein Biochemistry: Part B, Volume 678 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Precise modification of native proteins, purification, and analysis of bioconjugates, NanoBiT-based methods to monitor the activation and modulation of RTKs, The interplay of G-protein y subunit and PLC- enzyme in PIP2 hydrolysis and downstream signaling, Structure and function of bacterial secretion system, Tools and protocols for probing protein sumoylation, Spectroscopic analysis of cysteine dioxygenase: a mammalian thiol-dioxygenase, DeGlyPHER: MS-based analysis of viral spike N-glycoforms, and more.
Developments and Applications of Enzymes from Thermophilic Microorganisms extensively presents the industrial application of thermophilic/hyperthermophilic enzymes.
This volume provides new technologies on NRPSs and related carrier protein dependent synthases, including polyketide synthases (PKS) and fatty acid synthases (FAS).
Epigenetics in Health and Disease, Volume 198 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on Computational biology in epigenetics, Artificial intelligence and machine learning in epigenetics, CRISPR-dCas9 Systems for Epigenetic Editing for Therapeutic Applications, Epigenetics in heredity disease, Epigenetics in cancer development, diagnosis and therapy, Microbiota and epigenetics: health impact, Histone deacetylase (HDACs) Inhibitors: Clinical applications, Early epigenetic markers for precision medicine, Epigenetics of neurological diseases, Epigenetic Regulons in Alzheimer's disease, and Epigenetics in epilepsy.
Modifications and Targeting of Protein Termini, Volume 684 in the Methods in Enzymology series serial highlights new advances in the field, with this new volume presenting interesting chapters pn a variety of timely topics, including Optimizing purification and activity assays of N-terminal methyltransferase complexes, In vitro reconstitution of hierarchical steps of Arg/N-degron pathway, Identification of N-degrons and N-recognins by using peptide-pull-downs combined with quantitative proteomics, A decoupled Virotrap approach to study the interactomes of N-terminal proteoforms, Monitoring ADO-dependent proteolysis in cells using fluorescent reporter proteins, Site-specific a-N-terminal methylation on peptides through chemical and enzymatic methods, and more.
The human brain is made up of billions of neurons that communicate with each other through chemical messengers, which are referred to as neuroactive substances.
This volume provides new technologies on NRPSs and related carrier protein dependent synthases, including polyketide synthases (PKS) and fatty acid synthases (FAS).
Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is the dynamic integration of the processes of protein folding, degradation and translocation to ensure that cellular function is finely tuned in space and time.
Epigenetics in Health and Disease, Volume 198 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on Computational biology in epigenetics, Artificial intelligence and machine learning in epigenetics, CRISPR-dCas9 Systems for Epigenetic Editing for Therapeutic Applications, Epigenetics in heredity disease, Epigenetics in cancer development, diagnosis and therapy, Microbiota and epigenetics: health impact, Histone deacetylase (HDACs) Inhibitors: Clinical applications, Early epigenetic markers for precision medicine, Epigenetics of neurological diseases, Epigenetic Regulons in Alzheimer's disease, and Epigenetics in epilepsy.
Modifications and Targeting of Protein Termini, Volume 684 in the Methods in Enzymology series serial highlights new advances in the field, with this new volume presenting interesting chapters pn a variety of timely topics, including Optimizing purification and activity assays of N-terminal methyltransferase complexes, In vitro reconstitution of hierarchical steps of Arg/N-degron pathway, Identification of N-degrons and N-recognins by using peptide-pull-downs combined with quantitative proteomics, A decoupled Virotrap approach to study the interactomes of N-terminal proteoforms, Monitoring ADO-dependent proteolysis in cells using fluorescent reporter proteins, Site-specific a-N-terminal methylation on peptides through chemical and enzymatic methods, and more.
Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders.
Scattering Methods in Structural Biology, Part B, Volume 676 in the Methods in Enzymology serial, highlights advances in the field, presenting chapters on Quality controls, Refining biomolecular structures and ensembles by SAXS-driven molecular dynamics simulations, Data analysis and modelling of small-angle scattering data with contrast variation, Observing protein degradation in solution by the PAN-20S proteasome complex: state-of-the-art and future perspectives of TR-SANS as a complementary tool to NMR, crystallography and Cryo-EM, Extracting structural insights from chemically-specific soft X-ray scattering, Reconstruction of 3D density of biological macromolecules from solution scattering, ATSAS- present state and new developments in computational methods, and much more.
The incentive for putting together Volume 4 of this series was to review the wealth of new information that has become available in prokaryotic organisms in protein export and membrane biogenesis.
"e;Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology"e; represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins.
Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field.
Targeted Protein Degradation, Volume 680 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of timely topics, with each.
Molecular biotechnology is an exciting revolutionary scientific discipline that is based on the ability of a researcher to transfer specific units of genetic information from one organism to another.
In its broadest sense, molecular biotechnology is the use of laboratory techniques to study and modify nucleic acids and proteins for applications in areas such as human and animal health, agriculture, and the environment.
This book contains the latest material in the subject, covering next generation sequencing (NGS) applications and meeting the requirements of a complete semester course.
This book contains the latest material in the subject, covering next generation sequencing (NGS) applications and meeting the requirements of a complete semester course.
Arbuscular mycorrhizal fungi (AMF) are considered enormously important in contemporary agriculture and horticulture due to their important role in nutrient, biotic and abiotic stress management apart from enhancing plant health and soil fertility.
Growth of populations, increasing urbanization, and rising standards of living due to technological innovations demand not only the meticulous use of shrinking resources but also sustainable ways of producing materials for human welfare.
Bacterial biopolymers are a competitive new area of research with potential applications in agriculture, petroleum exploration, and use as biodegradable plastics.
