Medicinal chemistry

Pharmaceutical formulation design affects patient acceptability/adherence and pharmacokinetics of the drug.

This book focuses on direct nitrogenation strategies to incorporate one or more N-atoms into simple substrates especially hydrocarbons via C-H and/or C-C bond cleavage, which is a green and sustainable way to synthesize nitrogen-containing compounds.

As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets.

This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products.

This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners.

This book presents the recent research on sulfur-containing heterocyclic scaffolds that are crucial for biological processes.

This book presents recent advances in the use of ionic liquids in medicine and pharmaceutics with particular emphasis on addressing critical pharmaceutical challenges, including the low solubility, polymorphism, and bioavailability of drugs.

This book provides practical information on obtaining and using a wide variety of plant based reagents for different sectors, addressing the needs and challenges in a single resource.

Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines.

While the historic roots of clinical chemistry originate from the chemical sciences the growth of the subject has been dependent upon the poli- tical, social, economic and technologic national soil in which it has developed.

This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects.

This volume builds upon the successful book Lanthanide Luminescence published in the Springer Series on Fluorescence in 2011.

This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs.

This book brings together reviews from international experts who are exploring the biological activities of nanomaterials for medical applications or to better understand nanotoxicity.

One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA.

This book on "e;Renin-Angiotensin System in Cardiovascular Disease"e; includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects.

The articles in Issue 4 of Journal of Inherited Metabolic Disease, Vol.

Although the Bioequivalence (BE) requirements in many global jurisdictions have much in common, differences in certain approaches and requirements such as definitions and terms, choice of comparator (reference) product, acceptance criteria, fasted and fed studies, single and multi-dose studies, biowaivers and products not intended for absorption into the systemic circulation (locally acting medicines and dosage forms), amongst others, provide food for thought that standardisation should be a high priority objective in order to result in a harmonized international process for the market approval of products using BE.

This book introduces the recent development in Japan of diamond electrodes, which has attracted much attention in the world.

This monograph compiles updated information about forskolin, a labdane diterpene that is produced by the Coleus plant.

This book summarizes ourcurrent understanding about the biology and patho-biology of cardiomyocytes anddepicts common techniques for the study of these cells.

This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use.

This book covers sugar, salt and milk fat from a chemical perspective, and presents an overview of the role of these ingredients in our food, focusing on their flavors, satiety-inducing properties, nutritional impact, and health effects.

This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology.

Antimicrobial resistance is a major global public health problem.

This brief summarizes different types of organic and inorganic nanomaterials for drug delivery in cancer therapy.

This book helps clinicians to optimally and appropriately utilize homocysteine levels in the diagnosis, prediction and management of and research into vascular disease and many other conditions.

The book includes several topics as per Universities curriculum of M.

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects.

Proteins are exposed to various interfacial stresses during drug product development.

Two sigma receptor subtypes have been proposed, sigma1 and 2.

This book is the first to focus specifically on cancer nanotheranostics.

This book provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is of paramount importance for successful synthesis.

This updated and enlarged second edition is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases.

This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds.

'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry.

Medicinal chemistry is both science and art.

The book presents the current state of the art on phytocannnabinoid chemistry and pharmacology and will be of much use to those wishing to understand the current landscape of the exciting and intriguing phytocannabinoid science.

The book delves into the intricate realm of pharmacokinetics and pharmacodynamics as they apply to modern advancements in drug delivery systems.

In this brief the authors introduce a series of recently developed bio-based solvents including cyclopentyl methyl ether (CPME),  y-valerolactone (GVL), 2-methyl tetrahydrofuran (2-MeTHF), propylene carbonate (PC), and cyrene.

Thanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery.

This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring.

This book outlines the use of supramolecules as different pharmaceutical drugs.

This new edition is a comprehensive guide to the intricate world of drug discovery and development.

This revised and updated second edition contains multiple microscopic illustrations of all diagnostic entities and ancillary techniques, providing a comprehensive, authoritative guide to all aspects of serous effusions.

This book provides an overview of various drug delivery systems at the cellular level including biological, chemical methods, and most importantly physical methods such as photoporation, electroporation, mechanoporation, and device-based techniques (e.