Medicinal chemistry

This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products.

The development of new CNS drugs is notoriously difficult.

The development of innovative drugs is becoming more difficult while relying on empirical approaches.

This book deals with the noteworthy advancement in the production of bioactive metabolites from microbes and their pharmacological significance.

Alzheimer's Disease is a progressive neurodegenerative disorder of late life with devastating consequences for the afflicted and their carers and poses one of the major challenges to medical research.

This book presents the state of the art in glycoscience and proposes a road map for the coming decade, focusing on the potential of glycoscience research to shed light on important basic science issues and give rise to exciting new applications, especially in the field of diagnosis and therapeutics.

The book covers the totality of bilirubin (and heme from which bilirubin is derived biogenetically) the structural relationship of bilirubin to its solution properties and metabolism and to phototherapy for the jaundiced newborn - a common medical procedure used nowadays for lowering serum bilirubin, which is neurotoxic.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind.

This is a comprehensive textbook addressing the unique aspects of drug development for ophthalmic use.

Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry.

Potassium channels (K+) are membrane-spanning proteins which serve many important functions and are becoming a hot topic in physiology.

Salen Metal Complexes as Catalysts for the Synthesis of Polycarbonates from Cyclic Ethers and Carbon Dioxide, by Donald J.

After 13 years there are new areas to discuss and more recent trials to be included.

Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety, and stability of the final medicinal product.

This book explores technological innovation in family firms, seeking to reconstruct the links between the heterogeneous dimensions of family businesses and their innovative behaviour.

This collection provides detailed information on current advances in analytical methods and strategies employed for monitoring and discovering a wide range of novel psychoactive substances (NPS) in clinical and forensic laboratories.

2 Vol.

Embark on a transformative journey through uncharted realms of research and industry with the first book of the "e;Cannabis Innovations"e; series.

This book provides a broad account of various applied aspects of microbiology for quality and safety evaluations in food, water, soil, environment and pharmaceutical sciences.

Strategic decision-making focusing on economics is the fundamental requirement to generate efficiency and improve productivity in any manufacturing environment.

Cardiorespiratory function is prominently affected by oxidative stress.

In this book, tumour growth is perceived as a deviation from the normal development of the human organism.

This volume provides an overview of recent developments and scope in the use of flow chemistry in relevance to heterocyclic synthesis.

This book covers the most up-to-date photoaffinity labeling method to tackle the key loop module involved in the binding process of a bioactive small molecule to its host protein.

Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc.

This book reviews skin permeation and disposition of chemical compounds.

Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide.

This book is designed to provide pharmacologists and researchers of natural products a comprehensive review of 200 medicinal plants, their vernacular names in various languages and their medicinal uses around the world, and in some cases, a historical perspective.

This book is devoted to the graphics of patient data: good graphs enabling straight forward and intuitive interpretation, efficient creation, and straightforward interpretation.

This book provides an overview of the theories and applications on subgroups in the biopharmaceutical industry.

This contributed volume offers a comprehensive discussion on how to design and discover pharmaceuticals using computational modeling techniques.

This book on "e;Renin-Angiotensin System in Cardiovascular Disease"e; includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology.

The book HSP70 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP70 family - one of the most studied HSP - in human diseases and disorders.

Based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006, the book highlights the following topics: Structure of GPCRs, Design of GPCR Ligands, GPCR Signalling, Deorphanization and Assay Development.

Authored by leading experts from academia, users and manufacturers, this book provides an authoritative account of the science and technology involved in multiparticulate drug delivery systems which offer superior clinical and technical advantages over many other specialized approaches in drug delivery.

This work presents a systematic review of traditional herbal medicine and their active compounds, as well as their mechanism of action in the prevention and treatment of diabetes and obesity.

"e;Biobetters: Protein Engineering to Approach the Curative"e; discusses the optimization of protein therapeutic products for treatment of human diseases.

Molecular farming is a biotechnological approach that includes the genetic adjustment of agricultural products to create proteins and chemicals for profitable and pharmaceutical purposes.

This thesis presents a theoretical and experimental approach for the rapid fabrication, optimization and testing of holographic sensors for the quantification of pH, organic solvents, metal cations, and glucose in solutions.

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases.

This comprehensive, first-of-its kind title is an indispensable resource for pharmacists looking to learn or improve crucial patient assessment skills relevant to all pharmacy practice settings.

Now in its 2nd edition, this manual describes laboratory methodology for the diagnosis of inherited metabolic diseases.

Most of our knowledge of the physiological control of aldosterone secretion is based on animal experiments and clinical studies which were carried out in the 1950s and early 1960s by a large number of inspired, ingenious and meticulous researchers.

Molecular farming is a biotechnological approach that includes the genetic adjustment of agricultural products to create proteins and chemicals for profitable and pharmaceutical purposes.

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field.

The formation of disulphide bonds is probably the most influential modification of proteins.