Medicinal chemistry

The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules.

As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets.

This book covers the latest developments in rolling circle amplification (RCA) technology with applications in clinical diagnostic tests and molecular medicine.

Medicinal chemistry is both science and art.

Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals.

This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field.

This book describes 200 bio-polymers, including the most recent and advanced nanotechnology applications.

This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods.

This textbook discusses how the various types of antibiotics and related drugs work to cure infections.

The present book introduces an original (new) perspective on Cuba.

Medicinal chemistry is both science and art.

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds.

In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies.

This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline.

This thesis reports the latest developments in the direct amination of various C-H bonds using an H-Zn exchange/electrophilic amination strategy.

This book highlights the impact of nutrients on early placentation processes and their relevance for fetal growth and pregnancy outcome.

This fundamental book presents the most comprehensive summary of the current state in chemistry of cage metal complexes.

This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing.

Medicinal chemistry is both science and art.

The first contribution reviews the phytochemical, chemical,and biological literature on members of the ingenane class of diterpenoids fromtheir first isolation in 1968 through 2015, highlighting unresolved issues bothcommon to phorboids and specific to ingenol derivatives.

This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this.

This major reference work is a one-shot knowledge base on electroporation and the use of pulsed electric fields of high intensity and their use in biology, medicine, biotechnology, and food and environmental technologies.

This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs).

Medicinal chemistry is both science and art.

This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs.

Volume IV of this manual provides an overview of the analytical investigation of numerous additional Chinese Herbal Drugs, which are most commonly used in Traditional Chinese Medicine (TCM).

This second edition is a short and comprehensive study on the best known approaches for preparing the main types of glycosides.

This book constitutes a key reference on the use of algae in the biopharmaceuticals production field; providing an updated outlook on the achievements accomplished thus far and transmitting a prospective view for this biotechnological application.

This volume of Modern Aspects of Electrochemistry reviews the latest developments in electrochemical science and technology related to biomedical and pharmaceutical applications.

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds.

This book summarizes ourcurrent understanding about the biology and patho-biology of cardiomyocytes anddepicts common techniques for the study of these cells.

This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale.

Thisbook reviews the fundamental aspects of quinoxaline chemistry: synthesis,reactions, mechanisms, structure, properties, and uses.

This book investigates the relationship between phytoconstituentsand properties in specific plants, such as Hibiscus rosa sinesis, Cuscutareflexa, Citrullus colocynthis, Nardostachys jatamansi and Ocimumgratissimum, that are used in hair care products including shampoos,conditioners, dyes, and oils.

This second edition brings together up-to-date contributionsfrom leaders in the field internationally on the various ways in whichmitochondrial dysfunction contributes to the pathogenesis of neurodegenerativediseases, including Parkinson s disease, Alzheimer s disease and multiplesclerosis.

This completely revised and updated second edition showcases the considerable progress that has taken place in this field since 2008.

This book offers a thorough review of the scientific research that links the consumption of grapes to better health.

This volume gives an overview ofstate of the art technologies and future developments in the field ofpreclinical pharmaceutical research.

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes.

This consolidated reference book addresses the various aspects of nano biomaterials used in ophthalmic drug delivery, including their characterization, interactions with ophthalmic system and applications in treatments of the ophthalmic diseases and disorders.

Medicinal chemistry is both science and art.

This thesis investigates a range of experimental and computational approaches for the discovery of solid forms.

This bookdescribes the diverse roles that growth factors and cytokines play in skeletalmuscle.

This handbook compiles comprehensive reference information on sweeteners for academic researchers and professionals.

This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases.

This Brief discusses aspects of the increasingly complex production of legal and reliable food products of non-animal origin.

This is the first comprehensive reference compilation on the substance class of glucosinolates.

This book provides a comprehensive review of the literature available on satureja covering the ethnomedicine, micromorphology, the main secondary metabolites in its various species, as well it's important biological and pharmacological activities and the underlying mechanism of action for some of its medicinal properties.

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds.

This book is a wide-ranging guide to the diagnosis and management of the numerous medical and surgical complications that may arise in patients with sickle cell anemia.