Medicinal chemistry

This interdisciplinary book covers the fundamentals of optical whispering gallery mode (WGM) microcavities, light-matter interaction, and biomolecular structure with a focus on applications in biosensing.

This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp.

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology.

This third and final volume in the "e;Ion Transport in Tumor Biology"e; collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins.

This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues.

This volume focuses on the biomedical aspects of inorganic polyphosphates, a family of unique bio-inorganic polymers.

This second book of the three-volume collection "e;Ion Transport in Tumor Biology"e; helps readers gain comprehensive knowledge of the pathophysiology of cancer.

This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment.

This third edition is a comprehensive and extended study about the best known approaches for preparing the main types of glycosides, covering the classic and more recent glycosylation reactions used for preparing simple and challenging glycosides currently used as potent antiviral and antineoplastic drugs, or fluorogenic substrates used for enzymatic detection in cell biology.

The book provides a comprehensive review of the fundamental and practical aspects of bioanalytical support and the integral role it plays in the development of safe and efficacious biopharmaceutical drugs with speed and cost-effectiveness.

This volume discusses hazardous environmental micropollutants, their impacts on human health, and possible means to mitigate their associated risks.

The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug discovery, drug target identification, and validation.

This book provides a detailed summary of the therapeutic benefits of natural extracts from medicinal plants, mushrooms, algae, fungi and sponges and their role in the prevention and treatment of obesity and diabetes, offering readers a solid introduction to obesity and diabetes as well as current treatment models.

This volume gathers a selection of original articles and reviews on timely topics about the application of Taurine in human health written by members of the International Taurine Society, including COVID-19, cancer, heart disease, and diabetes, among others.

The purpose of this book is to highlight some of latest developments and applications of CRISPR, RNA, and DNA to treat diseases ranging from cancers to cardiovascular and degenerative disorders.

This book outlines the production of chitooligossacharides and their derivatives and discusses their main biological activities, biomedical applications and their role in disease prevention.

This volume consists of four chapters that cover a structurally diverse range of naturally occurring compounds.

This is the first of three volumes in the "e;Ion Channels & Transporters in Tumor Biology"e; collection, which discusses the function of ion transport proteins in cellular and systemic homeostasis.

This volume begins with a short history of malaria and follows with a summary of its biology.

The development of new CNS drugs is notoriously difficult.

The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules.

This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds.

This book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design.

Essentials of Industrial Pharmacy is an attempt to comprehensively present, in a single book, various pharmaceutical processes and equipment that are frequently used for production of pharmaceutical dosage forms, along with quality control tests of these dosage forms.

The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting.

Given novel infectious diseases such as COVID-19 and antibiotic resistance new antimicrobial discovery is an important research area.

This book provides targeted support for students taking courses at the undergraduate level involving electrochemical methods and voltammetry, precision analytical techniques used in chemical engineering, chemical research and development, and pharmaceutical science.

A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems.

This volume describes several highly diverse subjects: Chapter 1 explores marine biodiscovery of the North-eastern Atlantic off the coast of Ireland as a model for best practice in research.

This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field.

This book addresses the consequences of high agricultural pesticide use over the last few decades in the form of organophosphate poisoning.

Nuclear receptors are ligand activated transcription factors that control numerous biological functions.

The word stress is everywhere and highly overused.

This is a comprehensive textbook addressing the unique aspects of drug development for ophthalmic use.

This book presents the synthetic methodologies as well as the properties and potential usage of various ruthenium-containing materials.

Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc.

Due to their high nutritive value and the presence of secondary metabolites, wetland plants can be consumed by humans as food and utilized as medicinal drugs.

Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants.

This book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field.

This updated and enlarged second edition is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases.

This second edition of Clinical Use of Anti-Infective Agents provides a comprehensive overview of current approaches to using drugs to treat infections, including historical perspectives, definitions, and discussion of pharmacokinetics and pharmacodynamics and their uses.

This installment in the Techniques in Life Science and Biomedicine for the Non-Expert series aims to describe ESR spectroscopy as a tool for different applications, such as Healthcare & Pharmaceutical Science, Paleontology & Geochronology and Food Science.

This book describes current understandings and recent progress into a varied group of natural products.

The legislative requirement for cannabis to undergo laboratory testing has followed legalization of medical and recreational use in every U.

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology.

 This book describes current understandings and recent progress in four areas: in the first one, the cytochalasans, a group of fungal derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring are shown to exhibit high structural diversity and a broad spectrum of bioactivities.

To promote effectiveness and minimize possible toxicity, the dosage of certain medications must be adjusted in persons with compromised kidney function.