Pharmacology

Antibody-drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery.

The book contains reviews and posters of the 31st Congressof the EUROTOX (Maastricht 1991).

Rare Diseases and Orphan Drugs shows that much of what we now know about common diseases has been achieved by studying rare diseases.

This volume - for pharmacologists, systems biologists, philosophers and historians of medicine - points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm.

Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved.

In this book, the author provides expert analysis on naturally occurring iridoids, their chemistry and their distribution in plants and insects.

This book in the AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance.

Although research on carcinogenesis has focused more on cellular proliferation than on cell death, yet understanding the mechanism of apoptosis may have important implications for cancer therapy.

Optimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e.

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A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments.

In the present volume of the Handbook of Experimental Pharmacology well known experts describe the actions of different xanthines with a focus on caffeine and theophylline.

World renowned researchers discuss past and current research into REM sleep and set the foundation for future developments.

The book "e;Oxadiazole in Material and Medicinal Chemistry"e; is based on the utility of organic motifs that contain oxadiazole units in their molecular architecture.

The field of encapsulation, especially microencapsulation, is a rapidly growing area of research and product development.

Das neue Lehrbuch der Pharmazeutischen Biologie mit seinen Lehrinhalten für den zweiten Prüfungsabschnitt informiert über drei große Themenkreise biogener Arzneimittel: über pflanzliche Arzneimittel der besonderen Therapierichtungen mit Schwerpunkt Phytotherapie, über Arzneimittel aus Mikroorganismen, speziell über Antibiotika und Immuntherapeutika und über die neue Palette an Wirkstoffen, die gentechnisch hergestellt werden.

The idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature.

A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development.

Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine.

Progress in Nucleic Acid Research and Molecular Biology

The International Society of Chemotherapy meets every two years to review progress in chemotherapy of infections and of malignant disease.

Understanding the nature and role of endothelium-derived hyperpolarizing factor is crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion, and other vascular disorders.

Plant-based drugs play an important role in all cultures and have been crucial in maintaining health and fighting diseases, and by using contemporary methods of biotechnology, plants with explicit chemical compositions are propagated and genetically upgraded for the mining of pharmaceuticals.

This book provides a complete snapshot of various experimental approaches to structure-based and ligand-based drug design and is illustrated with more than 200 images.

This current edition explores new tests for genotoxicity testing, along with other well-known techniques.

A number of excellent symposia, reviews and monographs on the biology of ethanol have been published during the last decade.

This book is intended for students of medicine, pharmacy and other biological disciplines, who want to have a working knowledge of the mechanisms of action, uses and adverse effects of drugs which modify the activity of neurotransmitters in the peripheral and central nervous systems.

Pharmacogenomics: From Discovery to Clinical Implementation is a complete reference aimed at building a solid foundation of the key concepts in this fast-moving knowledge area.

Drug Safety in Developing Countries: Achievements and Challenges provides comprehensive information on drug safety issues in developing countries.

Advances in Pharmacology and Chemotherapy

Heterocyclic compounds are vital in synthetic chemistry, pharmaceuticals, agrochemicals, and materials science.

As with the two previous editions, Barile's Clinical Toxicology: Principles and Mechanisms, Third edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure.

Appreciation of the importance of platelets and coagulation factors in therothrombotic events has led to the widespread use and continuous development of new antithrombotic agents.

This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry.

Chronic hepatitis C infection (HCV) has been a global health burden since its discovery in 1989.

There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules.

This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines.

The majority of cancers present at a relatively advanced stage in which invasion within the primary organ is well established and metastases to lymph and distant organs are either clinically apparent or present at the microscopic level.

Most often when the subject of antimicrobial resistance is discussed, the organizational emphasis is on individual antimicrobial agents or groups of agents.

Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research.

This glossary addresses the need for harmonised toxicology terminology.

This is the first book about both normal development of the nervous system and how early exposure to alcohol and nicotine interferes with this development.

In recent years both doctors and patients have become increasingly aware that many essential drugs may induce unfortunate side-effects in susceptible individuals.